Development and Evaluation of Gastroretentive Atenolol Tablets
نویسندگان
چکیده
منابع مشابه
Formulation Development and In-Vitro Evaluation of Gastroretentive Floating tablets of Atenolol
The purpose of the study was to prolong the gastric residence time and increase the bioavailability of atenolol by designing its floating tablets and to study the influence of different polymers on its release rate. It was selected as a model drug, because it is poorly absorbed from the lower GIT. The tablets were prepared by direct compression technique, using different polymers such as hydrox...
متن کاملDevelopment and evaluation of gastroretentive norfloxacin floating tablets.
Floating matrix tablets of norfloxacin were developed to prolong gastric residence time, leading to an increase in drug bioavailability. Tablets were prepared by the wet granulation technique, using polymers such as hydroxypropyl methylcellulose (HPMC K4M, HPMC K100M) and xanthan gum. Tablets were evaluated for their physical characteristics, viz., hardness, thickness, friability, and mass vari...
متن کاملDevelopment and evaluation of regioselective bilayer floating tablets of Atenolol and Lovastatin for biphasic release profile
This study was performed to design bilayer regioselective floating tablets of atenolol and lovastatin to give immediate release of lovastatin and sustained release of atenolol. Bilayer floating tablets comprised two layers, i.e immediate release and controlled release layers. The immediate release layer comprised sodium starch glycollate as a super disintegrant and the sustained release layer c...
متن کاملDevelopment and evaluation of regioselective bilayer floating tablets of Atenolol and Lovastatin for biphasic release profile
This study was performed to design bilayer regioselective floating tablets of atenolol and lovastatin to give immediate release of lovastatin and sustained release of atenolol. Bilayer floating tablets comprised two layers, i.e immediate release and controlled release layers. The immediate release layer comprised sodium starch glycollate as a super disintegrant and the sustained release layer c...
متن کاملDevelopment and Evaluation of Gastroretentive Floating Drug Delivery System of Atenolol
Atenolol, an antihypertensive drug, has poor bioavailability (40-50%) and has has low elimination half life(6 hr). Atenolol is mainly absorbed in the stomach. The floating tablets of atenolol were prepared to increase the gastric retention, extend the drug release and to improve the bioavailability of the drug. The floating tablets were formulated using HPMC 100 cps, sodium alginate, carbopol 9...
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ژورنال
عنوان ژورنال: Zagazig Journal of Pharmaceutical Sciences
سال: 2014
ISSN: 2356-9786
DOI: 10.21608/zjps.2014.38181